While in the study, participants will be asked to do the following:

  1. Attend all study appointments. If you know that you will miss an appointment, contact the study staff to reschedule it as soon as possible.
  2. Stay in the study hotel in Southampton during the challenge phase of the study
  3. Follow the infection control rules.
  4. When asked by the study staff, accurately record your symptoms using the provided diary. The doctor or study nurse will show you how to do this.
  5. Tell the study staff about any side effects, GP (General Practitioner) or hospital visits that you may have, as well as any medicines or supplements you might be taking.
  6. You may request a copy of your vaccination history from your GP to bring with you to your screening visit
  7. Tell the study staff if you believe you or your partner might be pregnant. Use contraception as directed by the study staff until 3 months after the challenge.
  8. Ask questions as you think of them.
  9. Tell the study staff if you change your mind about staying in the study.
What are the inclusion and exclusion criteria?